| New Port Richey East to Storm Lake (Iowa) | 1,214.69 mi (1,954.86 km) |
| New Port Richey East to Storrs (Connecticut) | 1,104.91 mi (1,778.17 km) |
| New Port Richey East to Stoughton (Wisconsin) | 1,076.61 mi (1,732.64 km) |
| New Port Richey East to Stow (Ohio) | 895.24 mi (1,440.75 km) |
| New Port Richey East to Streamwood (Illinois) | 999.39 mi (1,608.37 km) |
| New Port Richey East to Streator (Illinois) | 954.07 mi (1,535.42 km) |
| New Port Richey East to Streetsboro (Ohio) | 899.99 mi (1,448.40 km) |
| New Port Richey East to Strongsville (Ohio) | 903.14 mi (1,453.46 km) |
| New Port Richey East to Stuart (Florida) | 166.84 mi (268.51 km) |
| New Port Richey East to Stuarts Draft (Virginia) | 706.48 mi (1,136.98 km) |
| New Port Richey East to Sturgis (Michigan) | 947.90 mi (1,525.50 km) |
| New Port Richey East to Suamico (Wisconsin) | 1,169.48 mi (1,882.09 km) |
| New Port Richey East to Sudley (Virginia) | 786.17 mi (1,265.22 km) |
| New Port Richey East to Suffern (New York) | 1,011.00 mi (1,627.05 km) |
| New Port Richey East to Suffolk (Virginia) | 680.88 mi (1,095.77 km) |
