| New Port Richey East to Southern Pines (North Carolina) | 516.41 mi (831.08 km) |
| New Port Richey East to Southfield (Michigan) | 982.74 mi (1,581.57 km) |
| New Port Richey East to Southgate (Michigan) | 963.88 mi (1,551.21 km) |
| New Port Richey East to Southlake (Texas) | 917.85 mi (1,477.13 km) |
| New Port Richey East to Spanaway (Washington) | 2,494.42 mi (4,014.38 km) |
| New Port Richey East to Spanish Fork (Utah) | 1,834.58 mi (2,952.47 km) |
| New Port Richey East to Spanish Lake (Missouri) | 845.67 mi (1,360.98 km) |
| New Port Richey East to Spanish Springs (Nevada) | 2,241.75 mi (3,607.75 km) |
| New Port Richey East to Sparks (Nevada) | 2,243.31 mi (3,610.25 km) |
| New Port Richey East to Spartanburg (South Carolina) | 464.00 mi (746.74 km) |
| New Port Richey East to Spearfish (South Dakota) | 1,615.04 mi (2,599.15 km) |
| New Port Richey East to Speedway (Indiana) | 822.25 mi (1,323.29 km) |
| New Port Richey East to Spencer (Iowa) | 1,240.55 mi (1,996.47 km) |
| New Port Richey East to Spokane (Washington) | 2,288.93 mi (3,683.67 km) |
| New Port Richey East to Spokane Valley (Washington) | 2,280.33 mi (3,669.84 km) |
