| New Port Richey East to Silver Firs (Washington) | 2,498.43 mi (4,020.83 km) |
| New Port Richey East to Silver Spring (Maryland) | 810.32 mi (1,304.09 km) |
| New Port Richey East to Silver Springs Shores (Florida) | 71.81 mi (115.56 km) |
| New Port Richey East to Silverdale (Washington) | 2,517.75 mi (4,051.93 km) |
| New Port Richey East to Silverton (Oregon) | 2,472.00 mi (3,978.31 km) |
| New Port Richey East to Simi Valley (California) | 2,157.94 mi (3,472.87 km) |
| New Port Richey East to Simpsonville (South Carolina) | 447.65 mi (720.42 km) |
| New Port Richey East to Sioux City (Iowa) | 1,246.65 mi (2,006.29 km) |
| New Port Richey East to Sioux Falls (South Dakota) | 1,311.96 mi (2,111.40 km) |
| New Port Richey East to Skokie (Illinois) | 993.08 mi (1,598.21 km) |
| New Port Richey East to Sleepy Hollow (New York) | 1,017.19 mi (1,637.02 km) |
| New Port Richey East to Slidell (Louisiana) | 449.58 mi (723.53 km) |
| New Port Richey East to Smithfield (North Carolina) | 562.01 mi (904.47 km) |
| New Port Richey East to Smithfield (Utah) | 1,882.58 mi (3,029.72 km) |
| New Port Richey East to Smithville (Missouri) | 1,025.99 mi (1,651.17 km) |
