| New Port Richey East to Seymour (Tennessee) | 530.07 mi (853.06 km) |
| New Port Richey East to Shady Hills (Florida) | 13.33 mi (21.46 km) |
| New Port Richey East to Shafter (California) | 2,186.37 mi (3,518.62 km) |
| New Port Richey East to Shaker Heights (Ohio) | 915.27 mi (1,472.98 km) |
| New Port Richey East to Shakopee (Minnesota) | 1,285.89 mi (2,069.44 km) |
| New Port Richey East to Sharon (Pennsylvania) | 904.90 mi (1,456.29 km) |
| New Port Richey East to Sharonville (Ohio) | 767.84 mi (1,235.71 km) |
| New Port Richey East to Shasta Lake (California) | 2,393.79 mi (3,852.43 km) |
| New Port Richey East to Shawnee (Kansas) | 1,016.84 mi (1,636.45 km) |
| New Port Richey East to Shawnee (Oklahoma) | 969.25 mi (1,559.85 km) |
| New Port Richey East to Sheboygan (Wisconsin) | 1,105.44 mi (1,779.03 km) |
| New Port Richey East to Shelby (North Carolina) | 490.36 mi (789.17 km) |
| New Port Richey East to Shelbyville (Indiana) | 798.71 mi (1,285.40 km) |
| New Port Richey East to Shelbyville (Kentucky) | 702.58 mi (1,130.70 km) |
| New Port Richey East to Shelbyville (Tennessee) | 546.44 mi (879.41 km) |
