| New Port Richey East to Security-Widefield (Colorado) | 1,455.41 mi (2,342.26 km) |
| New Port Richey East to Sedalia (Missouri) | 941.89 mi (1,515.83 km) |
| New Port Richey East to Sedro-Woolley (Washington) | 2,516.45 mi (4,049.84 km) |
| New Port Richey East to Seguin (Texas) | 927.58 mi (1,492.80 km) |
| New Port Richey East to Selden (New York) | 1,028.23 mi (1,654.78 km) |
| New Port Richey East to Selma (Alabama) | 386.50 mi (622.02 km) |
| New Port Richey East to Selma (California) | 2,214.03 mi (3,563.13 km) |
| New Port Richey East to Selma (Texas) | 948.33 mi (1,526.20 km) |
| New Port Richey East to Seminole (Florida) | 29.34 mi (47.22 km) |
| New Port Richey East to Seven Hills (Ohio) | 908.31 mi (1,461.79 km) |
| New Port Richey East to Seven Oaks (South Carolina) | 410.19 mi (660.13 km) |
| New Port Richey East to Severn (Maryland) | 826.18 mi (1,329.61 km) |
| New Port Richey East to Severna Park (Maryland) | 826.24 mi (1,329.71 km) |
| New Port Richey East to Sevierville (Tennessee) | 529.43 mi (852.03 km) |
| New Port Richey East to Seymour (Indiana) | 760.84 mi (1,224.46 km) |
