| New Port Richey East to Scottsboro (Alabama) | 483.28 mi (777.76 km) |
| New Port Richey East to Scottsdale (Arizona) | 1,762.13 mi (2,835.88 km) |
| New Port Richey East to Scranton (Pennsylvania) | 990.88 mi (1,594.67 km) |
| New Port Richey East to Seabrook (Maryland) | 812.89 mi (1,308.22 km) |
| New Port Richey East to Seabrook (Texas) | 750.87 mi (1,208.40 km) |
| New Port Richey East to Seaford (New York) | 1,003.41 mi (1,614.83 km) |
| New Port Richey East to Seagoville (Texas) | 878.22 mi (1,413.36 km) |
| New Port Richey East to Seal Beach (California) | 2,118.62 mi (3,409.58 km) |
| New Port Richey East to Searcy (Arkansas) | 716.92 mi (1,153.78 km) |
| New Port Richey East to Seaside (California) | 2,336.36 mi (3,760.00 km) |
| New Port Richey East to SeaTac (Washington) | 2,496.02 mi (4,016.96 km) |
| New Port Richey East to Seattle (Washington) | 2,500.91 mi (4,024.82 km) |
| New Port Richey East to Sebastian (Florida) | 138.86 mi (223.47 km) |
| New Port Richey East to Sebring (Florida) | 93.10 mi (149.83 km) |
| New Port Richey East to Secaucus (New Jersey) | 993.53 mi (1,598.93 km) |
