| New Port Richey East to Olympia Heights (Florida) | 227.41 mi (365.99 km) |
| New Port Richey East to Omaha (Nebraska) | 1,172.70 mi (1,887.28 km) |
| New Port Richey East to On Top of the World Designated Place (Florida) | 63.39 mi (102.02 km) |
| New Port Richey East to Onalaska (Wisconsin) | 1,178.22 mi (1,896.17 km) |
| New Port Richey East to Oneida (New York) | 1,096.11 mi (1,764.02 km) |
| New Port Richey East to Oneonta (New York) | 1,069.62 mi (1,721.39 km) |
| New Port Richey East to Ontario (California) | 2,092.29 mi (3,367.21 km) |
| New Port Richey East to Ontario (Oregon) | 2,178.61 mi (3,506.14 km) |
| New Port Richey East to Opa-locka (Florida) | 221.57 mi (356.59 km) |
| New Port Richey East to Opelika (Alabama) | 343.47 mi (552.77 km) |
| New Port Richey East to Opelousas (Louisiana) | 586.23 mi (943.44 km) |
| New Port Richey East to Orange (California) | 2,104.33 mi (3,386.59 km) |
| New Port Richey East to Orange (Texas) | 679.56 mi (1,093.65 km) |
| New Port Richey East to Orange City (Florida) | 97.13 mi (156.32 km) |
| New Port Richey East to Orangeburg (South Carolina) | 377.36 mi (607.31 km) |
