| New Port Richey East to Indianapolis (Indiana) | 819.73 mi (1,319.22 km) |
| New Port Richey East to Indianola (Iowa) | 1,093.38 mi (1,759.63 km) |
| New Port Richey East to Indio (California) | 2,013.08 mi (3,239.74 km) |
| New Port Richey East to Inglewood (California) | 2,134.45 mi (3,435.06 km) |
| New Port Richey East to Inkster (Michigan) | 970.21 mi (1,561.41 km) |
| New Port Richey East to Inver Grove Heights (Minnesota) | 1,278.48 mi (2,057.51 km) |
| New Port Richey East to Inwood (New York) | 993.24 mi (1,598.46 km) |
| New Port Richey East to Iona (Florida) | 128.65 mi (207.04 km) |
| New Port Richey East to Ionia (Michigan) | 1,025.46 mi (1,650.31 km) |
| New Port Richey East to Iowa City (Iowa) | 1,050.74 mi (1,691.00 km) |
| New Port Richey East to Irmo (South Carolina) | 413.17 mi (664.93 km) |
| New Port Richey East to Irondale (Alabama) | 434.16 mi (698.72 km) |
| New Port Richey East to Ironton (Ohio) | 709.71 mi (1,142.17 km) |
| New Port Richey East to Irvine (California) | 2,101.46 mi (3,381.97 km) |
| New Port Richey East to Irving (Texas) | 905.92 mi (1,457.94 km) |
