| New Port Richey East to Enterprise (Nevada) | 1,967.20 mi (3,165.90 km) |
| New Port Richey East to Enumclaw (Washington) | 2,477.13 mi (3,986.56 km) |
| New Port Richey East to Ephrata (Pennsylvania) | 903.07 mi (1,453.36 km) |
| New Port Richey East to Erie (Colorado) | 1,508.26 mi (2,427.30 km) |
| New Port Richey East to Erie (Pennsylvania) | 968.59 mi (1,558.80 km) |
| New Port Richey East to Erlanger (Kentucky) | 750.67 mi (1,208.08 km) |
| New Port Richey East to Escanaba (Michigan) | 1,231.86 mi (1,982.48 km) |
| New Port Richey East to Escondido (California) | 2,060.75 mi (3,316.46 km) |
| New Port Richey East to Española (New Mexico) | 1,463.97 mi (2,356.03 km) |
| New Port Richey East to Essex (Maryland) | 842.49 mi (1,355.86 km) |
| New Port Richey East to Essex Junction (Vermont) | 1,239.43 mi (1,994.66 km) |
| New Port Richey East to Estelle (Louisiana) | 460.59 mi (741.26 km) |
| New Port Richey East to Estero (Florida) | 138.11 mi (222.27 km) |
| New Port Richey East to Euclid (Ohio) | 923.37 mi (1,486.02 km) |
| New Port Richey East to Eufaula (Alabama) | 291.82 mi (469.64 km) |
