| New Port Richey East to Elyria (Ohio) | 906.80 mi (1,459.35 km) |
| New Port Richey East to Emeryville (California) | 2,367.59 mi (3,810.27 km) |
| New Port Richey East to Emmaus (Pennsylvania) | 941.24 mi (1,514.77 km) |
| New Port Richey East to Emporia (Kansas) | 1,045.91 mi (1,683.23 km) |
| New Port Richey East to Encinitas (California) | 2,071.68 mi (3,334.04 km) |
| New Port Richey East to Endicott (New York) | 1,025.91 mi (1,651.04 km) |
| New Port Richey East to Endwell (New York) | 1,028.06 mi (1,654.50 km) |
| New Port Richey East to Englewood (Colorado) | 1,494.42 mi (2,405.04 km) |
| New Port Richey East to Englewood (Florida) | 91.46 mi (147.19 km) |
| New Port Richey East to Englewood (New Jersey) | 1,002.57 mi (1,613.48 km) |
| New Port Richey East to Englewood (Ohio) | 807.01 mi (1,298.75 km) |
| New Port Richey East to Enid (Oklahoma) | 1,047.66 mi (1,686.04 km) |
| New Port Richey East to Ennis (Texas) | 877.05 mi (1,411.48 km) |
| New Port Richey East to Ensley (Florida) | 317.01 mi (510.18 km) |
| New Port Richey East to Enterprise (Alabama) | 283.96 mi (456.99 km) |
