| New Port Richey East to Des Plaines (Illinois) | 995.60 mi (1,602.26 km) |
| New Port Richey East to Desert Hot Springs (California) | 2,031.23 mi (3,268.95 km) |
| New Port Richey East to DeSoto (Texas) | 894.93 mi (1,440.26 km) |
| New Port Richey East to Destin (Florida) | 271.11 mi (436.30 km) |
| New Port Richey East to Destrehan (Louisiana) | 477.85 mi (769.03 km) |
| New Port Richey East to Detroit (Michigan) | 976.07 mi (1,570.83 km) |
| New Port Richey East to Diamond Bar (California) | 2,104.23 mi (3,386.44 km) |
| New Port Richey East to Diamond Springs (California) | 2,294.70 mi (3,692.97 km) |
| New Port Richey East to Dickinson (North Dakota) | 1,683.46 mi (2,709.27 km) |
| New Port Richey East to Dickinson (Texas) | 752.47 mi (1,210.98 km) |
| New Port Richey East to Dickson (Tennessee) | 604.27 mi (972.47 km) |
| New Port Richey East to Difficult Run (Virginia) | 796.62 mi (1,282.03 km) |
| New Port Richey East to Dinuba (California) | 2,201.96 mi (3,543.71 km) |
| New Port Richey East to Discovery Bay (California) | 2,330.23 mi (3,750.15 km) |
| New Port Richey East to Dix Hills (New York) | 1,015.71 mi (1,634.62 km) |
