| New Port Richey to Southern Pines (North Carolina) | 517.81 mi (833.34 km) |
| New Port Richey to Southfield (Michigan) | 983.65 mi (1,583.03 km) |
| New Port Richey to Southgate (Michigan) | 964.79 mi (1,552.67 km) |
| New Port Richey to Southlake (Texas) | 916.91 mi (1,475.63 km) |
| New Port Richey to Spanaway (Washington) | 2,493.98 mi (4,013.68 km) |
| New Port Richey to Spanish Fork (Utah) | 1,833.90 mi (2,951.38 km) |
| New Port Richey to Spanish Lake (Missouri) | 845.81 mi (1,361.19 km) |
| New Port Richey to Spanish Springs (Nevada) | 2,240.97 mi (3,606.50 km) |
| New Port Richey to Sparks (Nevada) | 2,242.52 mi (3,608.99 km) |
| New Port Richey to Spartanburg (South Carolina) | 465.08 mi (748.48 km) |
| New Port Richey to Spearfish (South Dakota) | 1,614.82 mi (2,598.80 km) |
| New Port Richey to Speedway (Indiana) | 822.84 mi (1,324.23 km) |
| New Port Richey to Spencer (Iowa) | 1,240.62 mi (1,996.58 km) |
| New Port Richey to Spokane (Washington) | 2,288.58 mi (3,683.12 km) |
| New Port Richey to Spokane Valley (Washington) | 2,279.99 mi (3,669.29 km) |
