| New Port Richey to Smyrna (Delaware) | 864.86 mi (1,391.85 km) |
| New Port Richey to Smyrna (Georgia) | 402.40 mi (647.59 km) |
| New Port Richey to Smyrna (Tennessee) | 578.09 mi (930.35 km) |
| New Port Richey to Snellville (Georgia) | 394.97 mi (635.65 km) |
| New Port Richey to Snoqualmie (Washington) | 2,477.12 mi (3,986.54 km) |
| New Port Richey to Snyder (Texas) | 1,124.82 mi (1,810.22 km) |
| New Port Richey to Socastee (South Carolina) | 435.30 mi (700.54 km) |
| New Port Richey to Socorro (Texas) | 1,426.02 mi (2,294.96 km) |
| New Port Richey to Soddy-Daisy (Tennessee) | 505.36 mi (813.30 km) |
| New Port Richey to Solana Beach (California) | 2,070.39 mi (3,331.96 km) |
| New Port Richey to Soledad (California) | 2,308.33 mi (3,714.90 km) |
| New Port Richey to Solon (Ohio) | 910.72 mi (1,465.66 km) |
| New Port Richey to Somers Point (New Jersey) | 894.56 mi (1,439.66 km) |
| New Port Richey to Somerset (Kentucky) | 620.36 mi (998.38 km) |
| New Port Richey to Somerset (New Jersey) | 967.00 mi (1,556.24 km) |
