| New Port Richey to Silver Firs (Washington) | 2,498.03 mi (4,020.19 km) |
| New Port Richey to Silver Spring (Maryland) | 811.75 mi (1,306.39 km) |
| New Port Richey to Silver Springs Shores (Florida) | 73.41 mi (118.15 km) |
| New Port Richey to Silverdale (Washington) | 2,517.34 mi (4,051.26 km) |
| New Port Richey to Silverton (Oregon) | 2,471.47 mi (3,977.44 km) |
| New Port Richey to Simi Valley (California) | 2,156.90 mi (3,471.20 km) |
| New Port Richey to Simpsonville (South Carolina) | 448.67 mi (722.07 km) |
| New Port Richey to Sioux City (Iowa) | 1,246.61 mi (2,006.23 km) |
| New Port Richey to Sioux Falls (South Dakota) | 1,311.98 mi (2,111.42 km) |
| New Port Richey to Skokie (Illinois) | 993.62 mi (1,599.07 km) |
| New Port Richey to Sleepy Hollow (New York) | 1,018.70 mi (1,639.44 km) |
| New Port Richey to Slidell (Louisiana) | 448.54 mi (721.85 km) |
| New Port Richey to Smithfield (North Carolina) | 563.50 mi (906.87 km) |
| New Port Richey to Smithfield (Utah) | 1,882.01 mi (3,028.80 km) |
| New Port Richey to Smithville (Missouri) | 1,025.83 mi (1,650.92 km) |
