| New Port Richey to Seymour (Tennessee) | 530.85 mi (854.31 km) |
| New Port Richey to Shady Hills (Florida) | 15.01 mi (24.16 km) |
| New Port Richey to Shafter (California) | 2,185.39 mi (3,517.05 km) |
| New Port Richey to Shaker Heights (Ohio) | 916.31 mi (1,474.65 km) |
| New Port Richey to Shakopee (Minnesota) | 1,286.15 mi (2,069.85 km) |
| New Port Richey to Sharon (Pennsylvania) | 906.02 mi (1,458.10 km) |
| New Port Richey to Sharonville (Ohio) | 768.60 mi (1,236.95 km) |
| New Port Richey to Shasta Lake (California) | 2,393.04 mi (3,851.23 km) |
| New Port Richey to Shawnee (Kansas) | 1,016.64 mi (1,636.12 km) |
| New Port Richey to Shawnee (Oklahoma) | 968.57 mi (1,558.76 km) |
| New Port Richey to Sheboygan (Wisconsin) | 1,106.02 mi (1,779.97 km) |
| New Port Richey to Shelby (North Carolina) | 491.50 mi (790.99 km) |
| New Port Richey to Shelbyville (Indiana) | 799.34 mi (1,286.41 km) |
| New Port Richey to Shelbyville (Kentucky) | 703.23 mi (1,131.73 km) |
| New Port Richey to Shelbyville (Tennessee) | 546.75 mi (879.91 km) |
