| New Port Richey to Sanford (Maine) | 1,241.44 mi (1,997.90 km) |
| New Port Richey to Sanford (North Carolina) | 541.58 mi (871.58 km) |
| New Port Richey to Sanger (California) | 2,210.64 mi (3,557.68 km) |
| New Port Richey to Santa Ana (California) | 2,106.66 mi (3,390.33 km) |
| New Port Richey to Santa Barbara (California) | 2,212.48 mi (3,560.65 km) |
| New Port Richey to Santa Clara (California) | 2,346.61 mi (3,776.50 km) |
| New Port Richey to Santa Clara (Oregon) | 2,474.29 mi (3,981.99 km) |
| New Port Richey to Santa Clarita (California) | 2,142.73 mi (3,448.39 km) |
| New Port Richey to Santa Cruz (California) | 2,348.61 mi (3,779.72 km) |
| New Port Richey to Santa Fe (New Mexico) | 1,452.50 mi (2,337.57 km) |
| New Port Richey to Santa Fe (Texas) | 753.42 mi (1,212.52 km) |
| New Port Richey to Santa Fe Springs (California) | 2,117.22 mi (3,407.33 km) |
| New Port Richey to Santa Maria (California) | 2,254.15 mi (3,627.70 km) |
| New Port Richey to Santa Monica (California) | 2,141.29 mi (3,446.08 km) |
| New Port Richey to Santa Paula (California) | 2,175.08 mi (3,500.46 km) |
