| New Port Richey to Olympia Heights (Florida) | 227.63 mi (366.34 km) |
| New Port Richey to Omaha (Nebraska) | 1,172.60 mi (1,887.11 km) |
| New Port Richey to On Top of the World Designated Place (Florida) | 64.83 mi (104.34 km) |
| New Port Richey to Onalaska (Wisconsin) | 1,178.58 mi (1,896.74 km) |
| New Port Richey to Oneida (New York) | 1,097.48 mi (1,766.23 km) |
| New Port Richey to Oneonta (New York) | 1,071.03 mi (1,723.66 km) |
| New Port Richey to Ontario (California) | 2,091.24 mi (3,365.53 km) |
| New Port Richey to Ontario (Oregon) | 2,178.09 mi (3,505.29 km) |
| New Port Richey to Opa-locka (Florida) | 221.89 mi (357.09 km) |
| New Port Richey to Opelika (Alabama) | 343.66 mi (553.06 km) |
| New Port Richey to Opelousas (Louisiana) | 585.13 mi (941.68 km) |
| New Port Richey to Orange (California) | 2,103.27 mi (3,384.88 km) |
| New Port Richey to Orange (Texas) | 678.37 mi (1,091.73 km) |
| New Port Richey to Orange City (Florida) | 98.87 mi (159.11 km) |
| New Port Richey to Orangeburg (South Carolina) | 378.68 mi (609.43 km) |
