| New Port Richey to Enterprise (Nevada) | 1,966.26 mi (3,164.39 km) |
| New Port Richey to Enumclaw (Washington) | 2,476.71 mi (3,985.88 km) |
| New Port Richey to Ephrata (Pennsylvania) | 904.50 mi (1,455.66 km) |
| New Port Richey to Erie (Colorado) | 1,507.71 mi (2,426.42 km) |
| New Port Richey to Erie (Pennsylvania) | 969.74 mi (1,560.64 km) |
| New Port Richey to Erlanger (Kentucky) | 751.41 mi (1,209.28 km) |
| New Port Richey to Escanaba (Michigan) | 1,232.54 mi (1,983.57 km) |
| New Port Richey to Escondido (California) | 2,059.66 mi (3,314.71 km) |
| New Port Richey to Española (New Mexico) | 1,463.11 mi (2,354.65 km) |
| New Port Richey to Essex (Maryland) | 843.94 mi (1,358.19 km) |
| New Port Richey to Essex Junction (Vermont) | 1,240.86 mi (1,996.97 km) |
| New Port Richey to Estelle (Louisiana) | 459.45 mi (739.41 km) |
| New Port Richey to Estero (Florida) | 137.84 mi (221.83 km) |
| New Port Richey to Euclid (Ohio) | 924.41 mi (1,487.70 km) |
| New Port Richey to Eufaula (Alabama) | 291.93 mi (469.81 km) |
