| New Port Richey to Elyria (Ohio) | 907.79 mi (1,460.95 km) |
| New Port Richey to Emeryville (California) | 2,366.72 mi (3,808.86 km) |
| New Port Richey to Emmaus (Pennsylvania) | 942.69 mi (1,517.11 km) |
| New Port Richey to Emporia (Kansas) | 1,045.57 mi (1,682.67 km) |
| New Port Richey to Encinitas (California) | 2,070.58 mi (3,332.28 km) |
| New Port Richey to Endicott (New York) | 1,027.29 mi (1,653.26 km) |
| New Port Richey to Endwell (New York) | 1,029.44 mi (1,656.72 km) |
| New Port Richey to Englewood (Colorado) | 1,493.85 mi (2,404.11 km) |
| New Port Richey to Englewood (Florida) | 90.88 mi (146.26 km) |
| New Port Richey to Englewood (New Jersey) | 1,004.08 mi (1,615.91 km) |
| New Port Richey to Englewood (Ohio) | 807.79 mi (1,300.02 km) |
| New Port Richey to Enid (Oklahoma) | 1,047.05 mi (1,685.06 km) |
| New Port Richey to Ennis (Texas) | 876.06 mi (1,409.88 km) |
| New Port Richey to Ensley (Florida) | 316.24 mi (508.95 km) |
| New Port Richey to Enterprise (Alabama) | 283.73 mi (456.61 km) |
