| New Port Richey to Effingham (Illinois) | 822.27 mi (1,323.32 km) |
| New Port Richey to Eggertsville (New York) | 1,040.16 mi (1,673.97 km) |
| New Port Richey to Egypt Lake-Leto (Florida) | 20.38 mi (32.81 km) |
| New Port Richey to El Cajon (California) | 2,053.22 mi (3,304.35 km) |
| New Port Richey to El Campo (Texas) | 823.51 mi (1,325.31 km) |
| New Port Richey to El Centro (California) | 1,971.86 mi (3,173.40 km) |
| New Port Richey to El Cerrito (California) | 2,367.66 mi (3,810.37 km) |
| New Port Richey to El Dorado (Arkansas) | 682.86 mi (1,098.96 km) |
| New Port Richey to El Dorado (Kansas) | 1,050.85 mi (1,691.18 km) |
| New Port Richey to El Dorado Hills (California) | 2,304.98 mi (3,709.51 km) |
| New Port Richey to El Mirage (Arizona) | 1,787.11 mi (2,876.07 km) |
| New Port Richey to El Monte (California) | 2,115.49 mi (3,404.55 km) |
| New Port Richey to El Paso (Texas) | 1,436.89 mi (2,312.45 km) |
| New Port Richey to El Paso de Robles (California) | 2,267.56 mi (3,649.28 km) |
| New Port Richey to El Reno (Oklahoma) | 1,025.01 mi (1,649.59 km) |
