| New Port Richey to Des Plaines (Illinois) | 996.12 mi (1,603.10 km) |
| New Port Richey to Desert Hot Springs (California) | 2,030.18 mi (3,267.26 km) |
| New Port Richey to DeSoto (Texas) | 893.97 mi (1,438.70 km) |
| New Port Richey to Destin (Florida) | 270.43 mi (435.22 km) |
| New Port Richey to Destrehan (Louisiana) | 476.72 mi (767.21 km) |
| New Port Richey to Detroit (Michigan) | 976.98 mi (1,572.30 km) |
| New Port Richey to Diamond Bar (California) | 2,103.19 mi (3,384.75 km) |
| New Port Richey to Diamond Springs (California) | 2,293.87 mi (3,691.63 km) |
| New Port Richey to Dickinson (North Dakota) | 1,683.41 mi (2,709.19 km) |
| New Port Richey to Dickinson (Texas) | 751.19 mi (1,208.92 km) |
| New Port Richey to Dickson (Tennessee) | 604.49 mi (972.83 km) |
| New Port Richey to Difficult Run (Virginia) | 798.03 mi (1,284.30 km) |
| New Port Richey to Dinuba (California) | 2,201.03 mi (3,542.22 km) |
| New Port Richey to Discovery Bay (California) | 2,329.36 mi (3,748.75 km) |
| New Port Richey to Dix Hills (New York) | 1,017.24 mi (1,637.09 km) |
