| Nacogdoches to Southern Pines (North Carolina) | 912.59 mi (1,468.67 km) |
| Nacogdoches to Southfield (Michigan) | 976.92 mi (1,572.20 km) |
| Nacogdoches to Southgate (Michigan) | 965.35 mi (1,553.58 km) |
| Nacogdoches to Southlake (Texas) | 172.82 mi (278.12 km) |
| Nacogdoches to Spanaway (Washington) | 1,813.18 mi (2,918.04 km) |
| Nacogdoches to Spanish Fork (Utah) | 1,114.87 mi (1,794.21 km) |
| Nacogdoches to Spanish Lake (Missouri) | 555.45 mi (893.92 km) |
| Nacogdoches to Spanish Springs (Nevada) | 1,504.44 mi (2,421.16 km) |
| Nacogdoches to Sparks (Nevada) | 1,505.49 mi (2,422.85 km) |
| Nacogdoches to Spartanburg (South Carolina) | 769.70 mi (1,238.72 km) |
| Nacogdoches to Spearfish (South Dakota) | 1,018.33 mi (1,638.84 km) |
| Nacogdoches to Speedway (Indiana) | 735.34 mi (1,183.42 km) |
| Nacogdoches to Spencer (Iowa) | 797.35 mi (1,283.21 km) |
| Nacogdoches to Spokane (Washington) | 1,631.54 mi (2,625.71 km) |
| Nacogdoches to Spokane Valley (Washington) | 1,623.78 mi (2,613.21 km) |
