| Nacogdoches to Olympia Heights (Florida) | 957.30 mi (1,540.62 km) |
| Nacogdoches to Omaha (Nebraska) | 671.20 mi (1,080.19 km) |
| Nacogdoches to On Top of the World Designated Place (Florida) | 756.87 mi (1,218.06 km) |
| Nacogdoches to Onalaska (Wisconsin) | 868.53 mi (1,397.76 km) |
| Nacogdoches to Oneida (New York) | 1,304.52 mi (2,099.43 km) |
| Nacogdoches to Oneonta (New York) | 1,309.41 mi (2,107.29 km) |
| Nacogdoches to Ontario (California) | 1,340.34 mi (2,157.07 km) |
| Nacogdoches to Ontario (Oregon) | 1,482.07 mi (2,385.16 km) |
| Nacogdoches to Opa-locka (Florida) | 956.18 mi (1,538.82 km) |
| Nacogdoches to Opelika (Alabama) | 547.33 mi (880.84 km) |
| Nacogdoches to Opelousas (Louisiana) | 169.72 mi (273.14 km) |
| Nacogdoches to Orange (California) | 1,352.58 mi (2,176.77 km) |
| Nacogdoches to Orange (Texas) | 115.80 mi (186.36 km) |
| Nacogdoches to Orange City (Florida) | 818.08 mi (1,316.57 km) |
| Nacogdoches to Orangeburg (South Carolina) | 812.65 mi (1,307.84 km) |
