| Muscle Shoals to Southern Pines (North Carolina) | 466.91 mi (751.41 km) |
| Muscle Shoals to Southfield (Michigan) | 583.95 mi (939.78 km) |
| Muscle Shoals to Southgate (Michigan) | 568.26 mi (914.53 km) |
| Muscle Shoals to Southlake (Texas) | 559.62 mi (900.63 km) |
| Muscle Shoals to Spanaway (Washington) | 1,985.36 mi (3,195.12 km) |
| Muscle Shoals to Spanish Fork (Utah) | 1,363.66 mi (2,194.59 km) |
| Muscle Shoals to Spanish Lake (Missouri) | 313.66 mi (504.79 km) |
| Muscle Shoals to Spanish Springs (Nevada) | 1,785.58 mi (2,873.62 km) |
| Muscle Shoals to Sparks (Nevada) | 1,788.00 mi (2,877.51 km) |
| Muscle Shoals to Spartanburg (South Carolina) | 324.00 mi (521.43 km) |
| Muscle Shoals to Spearfish (South Dakota) | 1,089.88 mi (1,753.99 km) |
| Muscle Shoals to Speedway (Indiana) | 357.17 mi (574.81 km) |
| Muscle Shoals to Spencer (Iowa) | 706.71 mi (1,137.34 km) |
| Muscle Shoals to Spokane (Washington) | 1,771.84 mi (2,851.50 km) |
| Muscle Shoals to Spokane Valley (Washington) | 1,763.03 mi (2,837.33 km) |
