| Muscle Shoals to Olympia Heights (Florida) | 759.70 mi (1,222.62 km) |
| Muscle Shoals to Omaha (Nebraska) | 642.03 mi (1,033.25 km) |
| Muscle Shoals to On Top of the World Designated Place (Florida) | 499.87 mi (804.46 km) |
| Muscle Shoals to Onalaska (Wisconsin) | 659.92 mi (1,062.04 km) |
| Muscle Shoals to Oneida (New York) | 862.03 mi (1,387.30 km) |
| Muscle Shoals to Oneonta (New York) | 861.23 mi (1,386.02 km) |
| Muscle Shoals to Ontario (California) | 1,703.22 mi (2,741.07 km) |
| Muscle Shoals to Ontario (Oregon) | 1,681.80 mi (2,706.60 km) |
| Muscle Shoals to Opa-locka (Florida) | 752.46 mi (1,210.97 km) |
| Muscle Shoals to Opelika (Alabama) | 193.72 mi (311.75 km) |
| Muscle Shoals to Opelousas (Louisiana) | 389.64 mi (627.06 km) |
| Muscle Shoals to Orange (California) | 1,718.32 mi (2,765.38 km) |
| Muscle Shoals to Orange (Texas) | 478.93 mi (770.76 km) |
| Muscle Shoals to Orange City (Florida) | 547.29 mi (880.77 km) |
| Muscle Shoals to Orangeburg (South Carolina) | 396.53 mi (638.15 km) |
