| Muscle Shoals to Enterprise (Nevada) | 1,551.80 mi (2,497.38 km) |
| Muscle Shoals to Enumclaw (Washington) | 1,967.14 mi (3,165.80 km) |
| Muscle Shoals to Ephrata (Pennsylvania) | 731.03 mi (1,176.48 km) |
| Muscle Shoals to Erie (Colorado) | 1,021.03 mi (1,643.19 km) |
| Muscle Shoals to Erie (Pennsylvania) | 652.89 mi (1,050.73 km) |
| Muscle Shoals to Erlanger (Kentucky) | 339.54 mi (546.44 km) |
| Muscle Shoals to Escanaba (Michigan) | 760.87 mi (1,224.51 km) |
| Muscle Shoals to Escondido (California) | 1,685.10 mi (2,711.90 km) |
| Muscle Shoals to Española (New Mexico) | 1,040.65 mi (1,674.76 km) |
| Muscle Shoals to Essex (Maryland) | 692.27 mi (1,114.10 km) |
| Muscle Shoals to Essex Junction (Vermont) | 1,022.30 mi (1,645.23 km) |
| Muscle Shoals to Estelle (Louisiana) | 367.83 mi (591.96 km) |
| Muscle Shoals to Estero (Florida) | 671.03 mi (1,079.92 km) |
| Muscle Shoals to Euclid (Ohio) | 577.72 mi (929.75 km) |
| Muscle Shoals to Eufaula (Alabama) | 242.62 mi (390.46 km) |
