| Mount Pleasant to Enterprise (Nevada) | 2,018.48 mi (3,248.44 km) |
| Mount Pleasant to Enumclaw (Washington) | 2,404.95 mi (3,870.39 km) |
| Mount Pleasant to Ephrata (Pennsylvania) | 544.97 mi (877.05 km) |
| Mount Pleasant to Erie (Colorado) | 1,480.93 mi (2,383.33 km) |
| Mount Pleasant to Erie (Pennsylvania) | 640.16 mi (1,030.24 km) |
| Mount Pleasant to Erlanger (Kentucky) | 501.89 mi (807.71 km) |
| Mount Pleasant to Escanaba (Michigan) | 970.96 mi (1,562.60 km) |
| Mount Pleasant to Escondido (California) | 2,147.25 mi (3,455.66 km) |
| Mount Pleasant to Española (New Mexico) | 1,507.00 mi (2,425.29 km) |
| Mount Pleasant to Essex (Maryland) | 483.67 mi (778.39 km) |
| Mount Pleasant to Essex Junction (Vermont) | 880.86 mi (1,417.61 km) |
| Mount Pleasant to Estelle (Louisiana) | 640.98 mi (1,031.55 km) |
| Mount Pleasant to Estero (Florida) | 459.53 mi (739.55 km) |
| Mount Pleasant to Euclid (Ohio) | 610.79 mi (982.98 km) |
| Mount Pleasant to Eufaula (Alabama) | 317.73 mi (511.34 km) |
