| Mount Pleasant to Elyria (Ohio) | 602.08 mi (968.96 km) |
| Mount Pleasant to Emeryville (California) | 2,397.63 mi (3,858.61 km) |
| Mount Pleasant to Emmaus (Pennsylvania) | 582.06 mi (936.73 km) |
| Mount Pleasant to Emporia (Kansas) | 994.40 mi (1,600.34 km) |
| Mount Pleasant to Encinitas (California) | 2,159.03 mi (3,474.62 km) |
| Mount Pleasant to Endicott (New York) | 670.92 mi (1,079.73 km) |
| Mount Pleasant to Endwell (New York) | 672.95 mi (1,083.01 km) |
| Mount Pleasant to Englewood (Colorado) | 1,473.30 mi (2,371.04 km) |
| Mount Pleasant to Englewood (Florida) | 433.73 mi (698.02 km) |
| Mount Pleasant to Englewood (New Jersey) | 642.17 mi (1,033.47 km) |
| Mount Pleasant to Englewood (Ohio) | 544.74 mi (876.67 km) |
| Mount Pleasant to Enid (Oklahoma) | 1,053.39 mi (1,695.27 km) |
| Mount Pleasant to Ennis (Texas) | 978.49 mi (1,574.73 km) |
| Mount Pleasant to Ensley (Florida) | 466.62 mi (750.95 km) |
| Mount Pleasant to Enterprise (Alabama) | 368.10 mi (592.40 km) |
