| Mount Pleasant to Des Plaines (Illinois) | 773.03 mi (1,244.08 km) |
| Mount Pleasant to Desert Hot Springs (California) | 2,108.15 mi (3,392.73 km) |
| Mount Pleasant to DeSoto (Texas) | 989.71 mi (1,592.79 km) |
| Mount Pleasant to Destin (Florida) | 426.41 mi (686.23 km) |
| Mount Pleasant to Destrehan (Louisiana) | 652.90 mi (1,050.74 km) |
| Mount Pleasant to Detroit (Michigan) | 682.35 mi (1,098.13 km) |
| Mount Pleasant to Diamond Bar (California) | 2,179.83 mi (3,508.10 km) |
| Mount Pleasant to Diamond Springs (California) | 2,314.96 mi (3,725.56 km) |
| Mount Pleasant to Dickinson (North Dakota) | 1,547.06 mi (2,489.75 km) |
| Mount Pleasant to Dickinson (Texas) | 930.18 mi (1,496.98 km) |
| Mount Pleasant to Dickson (Tennessee) | 483.54 mi (778.18 km) |
| Mount Pleasant to Difficult Run (Virginia) | 440.16 mi (708.37 km) |
| Mount Pleasant to Dinuba (California) | 2,246.88 mi (3,616.00 km) |
| Mount Pleasant to Discovery Bay (California) | 2,359.51 mi (3,797.26 km) |
| Mount Pleasant to Dix Hills (New York) | 655.46 mi (1,054.86 km) |
