| Most to Southern Pines (North Carolina) | 4,514.88 mi (7,266.00 km) |
| Most to Southfield (Michigan) | 4,304.89 mi (6,928.06 km) |
| Most to Southgate (Michigan) | 4,316.07 mi (6,946.05 km) |
| Most to Southlake (Texas) | 5,298.22 mi (8,526.66 km) |
| Most to Spanaway (Washington) | 5,203.87 mi (8,374.81 km) |
| Most to Spanish Fork (Utah) | 5,355.66 mi (8,619.11 km) |
| Most to Spanish Lake (Missouri) | 4,740.24 mi (7,628.69 km) |
| Most to Spanish Springs (Nevada) | 5,595.90 mi (9,005.73 km) |
| Most to Sparks (Nevada) | 5,602.14 mi (9,015.78 km) |
| Most to Spartanburg (South Carolina) | 4,626.12 mi (7,445.02 km) |
| Most to Spearfish (South Dakota) | 4,880.32 mi (7,854.12 km) |
| Most to Speedway (Indiana) | 4,546.06 mi (7,316.18 km) |
| Most to Spencer (Iowa) | 4,682.81 mi (7,536.26 km) |
| Most to Spokane (Washington) | 5,057.59 mi (8,139.40 km) |
| Most to Spokane Valley (Washington) | 5,053.23 mi (8,132.38 km) |
