| Most to Smyrna (Delaware) | 4,167.63 mi (6,707.15 km) |
| Most to Smyrna (Georgia) | 4,781.40 mi (7,694.91 km) |
| Most to Smyrna (Tennessee) | 4,750.34 mi (7,644.93 km) |
| Most to Snellville (Georgia) | 4,761.90 mi (7,663.54 km) |
| Most to Snoqualmie (Washington) | 5,164.87 mi (8,312.05 km) |
| Most to Snyder (Texas) | 5,442.68 mi (8,759.15 km) |
| Most to Socastee (South Carolina) | 4,573.82 mi (7,360.86 km) |
| Most to Socorro (Texas) | 5,682.85 mi (9,145.66 km) |
| Most to Soddy-Daisy (Tennessee) | 4,735.51 mi (7,621.06 km) |
| Most to Solana Beach (California) | 5,937.19 mi (9,554.98 km) |
| Most to Soledad (California) | 5,834.91 mi (9,390.38 km) |
| Most to Solon (Ohio) | 4,290.63 mi (6,905.10 km) |
| Most to Somers Point (New Jersey) | 4,127.23 mi (6,642.14 km) |
| Most to Somerset (Kentucky) | 4,621.62 mi (7,437.78 km) |
| Most to Somerset (New Jersey) | 4,067.66 mi (6,546.26 km) |
