| Most to Scottsboro (Alabama) | 4,800.20 mi (7,725.17 km) |
| Most to Scottsdale (Arizona) | 5,739.54 mi (9,236.90 km) |
| Most to Scranton (Pennsylvania) | 4,071.29 mi (6,552.11 km) |
| Most to Seabrook (Maryland) | 4,230.96 mi (6,809.07 km) |
| Most to Seabrook (Texas) | 5,405.61 mi (8,699.49 km) |
| Most to Seaford (New York) | 4,020.87 mi (6,470.96 km) |
| Most to Seagoville (Texas) | 5,293.18 mi (8,518.55 km) |
| Most to Seal Beach (California) | 5,913.61 mi (9,517.03 km) |
| Most to Searcy (Arkansas) | 4,980.75 mi (8,015.74 km) |
| Most to Seaside (California) | 5,835.78 mi (9,391.78 km) |
| Most to SeaTac (Washington) | 5,179.90 mi (8,336.24 km) |
| Most to Seattle (Washington) | 5,169.60 mi (8,319.67 km) |
| Most to Sebastian (Florida) | 4,931.99 mi (7,937.27 km) |
| Most to Sebring (Florida) | 4,987.37 mi (8,026.39 km) |
| Most to Secaucus (New Jersey) | 4,038.10 mi (6,498.69 km) |
