| Most to Santa Rosa (California) | 5,744.60 mi (9,245.05 km) |
| Most to Santaquin (Utah) | 5,368.13 mi (8,639.18 km) |
| Most to Santee (California) | 5,937.96 mi (9,556.23 km) |
| Most to Sapulpa (Oklahoma) | 5,095.26 mi (8,200.03 km) |
| Most to Saraland (Alabama) | 5,075.96 mi (8,168.96 km) |
| Most to Sarasota (Florida) | 5,038.88 mi (8,109.30 km) |
| Most to Sarasota Springs (Florida) | 5,037.65 mi (8,107.32 km) |
| Most to Saratoga (California) | 5,800.97 mi (9,335.76 km) |
| Most to Saratoga Springs (New York) | 3,922.92 mi (6,313.33 km) |
| Most to Saratoga Springs (Utah) | 5,349.61 mi (8,609.37 km) |
| Most to Sartell (Minnesota) | 4,523.88 mi (7,280.49 km) |
| Most to Satellite Beach (Florida) | 4,916.58 mi (7,912.46 km) |
| Most to Sauk Rapids (Minnesota) | 4,522.80 mi (7,278.74 km) |
| Most to Sault Ste. Marie (Michigan) | 4,152.22 mi (6,682.35 km) |
| Most to Savage (Minnesota) | 4,540.59 mi (7,307.37 km) |
