| Most to Sanford (Maine) | 3,790.53 mi (6,100.27 km) |
| Most to Sanford (North Carolina) | 4,491.38 mi (7,228.18 km) |
| Most to Sanger (California) | 5,773.71 mi (9,291.89 km) |
| Most to Santa Ana (California) | 5,909.48 mi (9,510.38 km) |
| Most to Santa Barbara (California) | 5,916.83 mi (9,522.22 km) |
| Most to Santa Clara (California) | 5,793.59 mi (9,323.88 km) |
| Most to Santa Clara (Oregon) | 5,403.32 mi (8,695.80 km) |
| Most to Santa Clarita (California) | 5,884.82 mi (9,470.70 km) |
| Most to Santa Cruz (California) | 5,819.07 mi (9,364.88 km) |
| Most to Santa Fe (New Mexico) | 5,443.55 mi (8,760.55 km) |
| Most to Santa Fe (Texas) | 5,418.59 mi (8,720.38 km) |
| Most to Santa Fe Springs (California) | 5,902.51 mi (9,499.17 km) |
| Most to Santa Maria (California) | 5,904.82 mi (9,502.89 km) |
| Most to Santa Monica (California) | 5,908.38 mi (9,508.62 km) |
| Most to Santa Paula (California) | 5,903.95 mi (9,501.49 km) |
