| Most to Enumclaw (Washington) | 5,188.15 mi (8,349.52 km) |
| Most to Ephrata (Pennsylvania) | 4,148.23 mi (6,675.94 km) |
| Most to Erie (Colorado) | 5,165.83 mi (8,313.60 km) |
| Most to Erie (Pennsylvania) | 4,204.86 mi (6,767.08 km) |
| Most to Erlanger (Kentucky) | 4,524.07 mi (7,280.78 km) |
| Most to Escanaba (Michigan) | 4,280.92 mi (6,889.48 km) |
| Most to Escondido (California) | 5,923.51 mi (9,532.97 km) |
| Most to Española (New Mexico) | 5,426.74 mi (8,733.50 km) |
| Most to Essex (Maryland) | 4,199.90 mi (6,759.08 km) |
| Most to Essex Junction (Vermont) | 3,834.30 mi (6,170.70 km) |
| Most to Estelle (Louisiana) | 5,205.85 mi (8,378.01 km) |
| Most to Estero (Florida) | 5,055.60 mi (8,136.19 km) |
| Most to Euclid (Ohio) | 4,283.74 mi (6,894.02 km) |
| Most to Eufaula (Alabama) | 4,906.29 mi (7,895.90 km) |
| Most to Eugene (Oregon) | 5,406.59 mi (8,701.07 km) |
