| Most to Emeryville (California) | 5,772.26 mi (9,289.55 km) |
| Most to Emmaus (Pennsylvania) | 4,105.19 mi (6,606.66 km) |
| Most to Emporia (Kansas) | 4,969.55 mi (7,997.71 km) |
| Most to Encinitas (California) | 5,933.97 mi (9,549.79 km) |
| Most to Endicott (New York) | 4,054.54 mi (6,525.15 km) |
| Most to Endwell (New York) | 4,051.99 mi (6,521.05 km) |
| Most to Englewood (Colorado) | 5,186.62 mi (8,347.06 km) |
| Most to Englewood (Florida) | 5,050.15 mi (8,127.43 km) |
| Most to Englewood (New Jersey) | 4,029.40 mi (6,484.70 km) |
| Most to Englewood (Ohio) | 4,471.28 mi (7,195.83 km) |
| Most to Enid (Oklahoma) | 5,134.80 mi (8,263.66 km) |
| Most to Ennis (Texas) | 5,314.25 mi (8,552.45 km) |
| Most to Ensley (Florida) | 5,060.86 mi (8,144.66 km) |
| Most to Enterprise (Alabama) | 4,963.56 mi (7,988.09 km) |
| Most to Enterprise (Nevada) | 5,699.00 mi (9,171.65 km) |
