| Most to Desert Hot Springs (California) | 5,859.17 mi (9,429.42 km) |
| Most to DeSoto (Texas) | 5,307.45 mi (8,541.51 km) |
| Most to Destin (Florida) | 5,036.43 mi (8,105.35 km) |
| Most to Destrehan (Louisiana) | 5,209.73 mi (8,384.25 km) |
| Most to Detroit (Michigan) | 4,303.65 mi (6,926.06 km) |
| Most to Diamond Bar (California) | 5,891.74 mi (9,481.84 km) |
| Most to Diamond Springs (California) | 5,684.00 mi (9,147.51 km) |
| Most to Dickinson (North Dakota) | 4,718.42 mi (7,593.56 km) |
| Most to Dickinson (Texas) | 5,413.47 mi (8,712.14 km) |
| Most to Dickson (Tennessee) | 4,776.92 mi (7,687.71 km) |
| Most to Difficult Run (Virginia) | 4,254.04 mi (6,846.22 km) |
| Most to Dinuba (California) | 5,778.98 mi (9,300.37 km) |
| Most to Discovery Bay (California) | 5,751.08 mi (9,255.47 km) |
| Most to Dix Hills (New York) | 4,008.60 mi (6,451.21 km) |
| Most to Dixon (California) | 5,723.26 mi (9,210.70 km) |
