| Most to Santander | 951.82 mi (1,531.81 km) |
| Most to Santany | 924.08 mi (1,487.16 km) |
| Most to Santiago de Compostela | 1,169.71 mi (1,882.47 km) |
| Most to Santiago del Teide | 2,207.08 mi (3,551.95 km) |
| Most to Santiponce | 1,323.86 mi (2,130.55 km) |
| Most to Santomera | 1,121.26 mi (1,804.49 km) |
| Most to Santona | 938.80 mi (1,510.85 km) |
| Most to Santurce-Antiguo | 926.56 mi (1,491.16 km) |
| Most to Sarria | 1,126.64 mi (1,813.15 km) |
| Most to Sauzal | 2,182.96 mi (3,513.14 km) |
| Most to Sedavi | 1,023.95 mi (1,647.89 km) |
| Most to Segorbe | 1,004.11 mi (1,615.96 km) |
| Most to Segovia | 1,076.64 mi (1,732.69 km) |
| Most to Senmanat | 823.80 mi (1,325.78 km) |
| Most to Sesena | 1,102.40 mi (1,774.15 km) |
