| Most to Santeramo in Colle | 687.08 mi (1,105.76 km) |
| Most to Santo Stefano di Magra | 471.33 mi (758.53 km) |
| Most to Santo Stino di Livenza | 332.47 mi (535.07 km) |
| Most to Sarezzo | 370.85 mi (596.83 km) |
| Most to Sarno | 670.92 mi (1,079.74 km) |
| Most to Saronno | 398.17 mi (640.80 km) |
| Most to Sarzana | 473.73 mi (762.40 km) |
| Most to Sassari | 718.24 mi (1,155.90 km) |
| Most to Sasso Marconi | 436.12 mi (701.86 km) |
| Most to Sassuolo | 432.09 mi (695.39 km) |
| Most to Sava | 723.29 mi (1,164.02 km) |
| Most to Saviano | 663.70 mi (1,068.13 km) |
| Most to Savigliano | 491.42 mi (790.87 km) |
| Most to Savignano sul Panaro | 433.25 mi (697.25 km) |
| Most to Savignano sul Rubicone | 447.03 mi (719.42 km) |
