| Morro Bay to Southern Pines (North Carolina) | 2,320.05 mi (3,733.76 km) |
| Morro Bay to Southfield (Michigan) | 2,061.35 mi (3,317.42 km) |
| Morro Bay to Southgate (Michigan) | 2,063.88 mi (3,321.49 km) |
| Morro Bay to Southlake (Texas) | 1,361.79 mi (2,191.58 km) |
| Morro Bay to Spanaway (Washington) | 814.52 mi (1,310.84 km) |
| Morro Bay to Spanish Fork (Utah) | 599.87 mi (965.40 km) |
| Morro Bay to Spanish Lake (Missouri) | 1,697.42 mi (2,731.73 km) |
| Morro Bay to Spanish Springs (Nevada) | 303.27 mi (488.06 km) |
| Morro Bay to Sparks (Nevada) | 297.11 mi (478.16 km) |
| Morro Bay to Spartanburg (South Carolina) | 2,184.50 mi (3,515.62 km) |
| Morro Bay to Spearfish (South Dakota) | 1,097.22 mi (1,765.80 km) |
| Morro Bay to Speedway (Indiana) | 1,906.98 mi (3,068.98 km) |
| Morro Bay to Spencer (Iowa) | 1,468.68 mi (2,363.61 km) |
| Morro Bay to Spokane (Washington) | 867.71 mi (1,396.44 km) |
| Morro Bay to Spokane Valley (Washington) | 869.53 mi (1,399.37 km) |
