| Missouri City to Southern Pines (North Carolina) | 1,016.96 mi (1,636.64 km) |
| Missouri City to Southfield (Michigan) | 1,122.91 mi (1,807.15 km) |
| Missouri City to Southgate (Michigan) | 1,110.76 mi (1,787.60 km) |
| Missouri City to Southlake (Texas) | 252.96 mi (407.10 km) |
| Missouri City to Spanaway (Washington) | 1,878.39 mi (3,022.97 km) |
| Missouri City to Spanish Fork (Utah) | 1,165.13 mi (1,875.09 km) |
| Missouri City to Spanish Lake (Missouri) | 706.10 mi (1,136.36 km) |
| Missouri City to Spanish Springs (Nevada) | 1,532.58 mi (2,466.44 km) |
| Missouri City to Sparks (Nevada) | 1,533.00 mi (2,467.13 km) |
| Missouri City to Spartanburg (South Carolina) | 876.89 mi (1,411.21 km) |
| Missouri City to Spearfish (South Dakota) | 1,126.52 mi (1,812.95 km) |
| Missouri City to Speedway (Indiana) | 881.02 mi (1,417.87 km) |
| Missouri City to Spencer (Iowa) | 938.79 mi (1,510.83 km) |
| Missouri City to Spokane (Washington) | 1,709.18 mi (2,750.66 km) |
| Missouri City to Spokane Valley (Washington) | 1,701.85 mi (2,738.86 km) |
