| Mission Viejo to Denver (Colorado) | 824.64 mi (1,327.13 km) |
| Mission Viejo to Portland (Oregon) | 865.52 mi (1,392.92 km) |
| Mission Viejo to Seattle (Washington) | 998.11 mi (1,606.30 km) |
| Mission Viejo to Dallas (Texas) | 1,206.91 mi (1,942.33 km) |
| Mission Viejo to Houston (Texas) | 1,332.61 mi (2,144.63 km) |
| Mission Viejo to Minneapolis (Minnesota) | 1,512.98 mi (2,434.90 km) |
| Mission Viejo to St. Louis (Missouri) | 1,562.43 mi (2,514.48 km) |
| Mission Viejo to Chicago (Illinois) | 1,723.21 mi (2,773.24 km) |
| Mission Viejo to Atlanta (Georgia) | 1,902.23 mi (3,061.35 km) |
| Mission Viejo to Detroit (Michigan) | 1,961.11 mi (3,156.10 km) |
| Mission Viejo to Tampa (Florida) | 2,114.92 mi (3,403.64 km) |
| Mission Viejo to Washington (District of Columbia) | 2,274.55 mi (3,660.53 km) |
| Mission Viejo to Baltimore (Maryland) | 2,294.43 mi (3,692.53 km) |
| Mission Viejo to Miami (Florida) | 2,298.28 mi (3,698.72 km) |
| Mission Viejo to Philadelphia (Pennsylvania) | 2,370.46 mi (3,814.89 km) |
| Mission Viejo to Brooklyn (New York) | 2,430.54 mi (3,911.58 km) |
| Mission Viejo to New York (New York) | 2,431.69 mi (3,913.42 km) |
| Mission Viejo to Queens (New York) | 2,438.17 mi (3,923.85 km) |
| Mission Viejo to Los Angeles (California) | 55.45 mi (89.24 km) |
| Mission Viejo to San Diego (California) | 61.97 mi (99.73 km) |
| Mission Viejo to Las Vegas (Nevada) | 226.23 mi (364.09 km) |
| Mission Viejo to Boston (Massachusetts) | 2,573.66 mi (4,141.90 km) |
| Mission Viejo to Riverside (California) | 27.18 mi (43.73 km) |
| Mission Viejo to Phoenix (Arizona) | 320.32 mi (515.50 km) |
| Mission Viejo to San Francisco (California) | 392.72 mi (632.03 km) |
