| Minneapolis to Southern Pines (North Carolina) | 993.89 mi (1,599.51 km) |
| Minneapolis to Southfield (Michigan) | 528.01 mi (849.75 km) |
| Minneapolis to Southgate (Michigan) | 538.00 mi (865.83 km) |
| Minneapolis to Southlake (Texas) | 855.28 mi (1,376.44 km) |
| Minneapolis to Spanaway (Washington) | 1,398.13 mi (2,250.08 km) |
| Minneapolis to Spanish Fork (Utah) | 991.00 mi (1,594.86 km) |
| Minneapolis to Spanish Lake (Missouri) | 454.68 mi (731.74 km) |
| Minneapolis to Spanish Springs (Nevada) | 1,391.04 mi (2,238.66 km) |
| Minneapolis to Sparks (Nevada) | 1,395.65 mi (2,246.08 km) |
| Minneapolis to Spartanburg (South Carolina) | 914.76 mi (1,472.17 km) |
| Minneapolis to Spearfish (South Dakota) | 518.43 mi (834.33 km) |
| Minneapolis to Speedway (Indiana) | 505.55 mi (813.60 km) |
| Minneapolis to Spencer (Iowa) | 156.59 mi (252.00 km) |
| Minneapolis to Spokane (Washington) | 1,163.34 mi (1,872.22 km) |
| Minneapolis to Spokane Valley (Washington) | 1,154.11 mi (1,857.36 km) |
