| Middletown to Storm Lake (Iowa) | 603.83 mi (971.78 km) |
| Middletown to Storrs (Connecticut) | 654.05 mi (1,052.59 km) |
| Middletown to Stoughton (Wisconsin) | 345.67 mi (556.31 km) |
| Middletown to Stow (Ohio) | 192.85 mi (310.37 km) |
| Middletown to Streamwood (Illinois) | 264.63 mi (425.88 km) |
| Middletown to Streator (Illinois) | 260.44 mi (419.14 km) |
| Middletown to Streetsboro (Ohio) | 199.15 mi (320.50 km) |
| Middletown to Strongsville (Ohio) | 182.78 mi (294.15 km) |
| Middletown to Stuart (Florida) | 882.72 mi (1,420.59 km) |
| Middletown to Stuarts Draft (Virginia) | 304.89 mi (490.68 km) |
| Middletown to Sturgis (Michigan) | 167.94 mi (270.28 km) |
| Middletown to Suamico (Wisconsin) | 402.13 mi (647.17 km) |
| Middletown to Sudley (Virginia) | 371.33 mi (597.60 km) |
| Middletown to Suffern (New York) | 549.70 mi (884.65 km) |
| Middletown to Suffolk (Virginia) | 462.51 mi (744.33 km) |
