| Middletown to Southern Pines (North Carolina) | 403.58 mi (649.49 km) |
| Middletown to Southfield (Michigan) | 213.36 mi (343.37 km) |
| Middletown to Southgate (Michigan) | 196.24 mi (315.82 km) |
| Middletown to Southlake (Texas) | 842.77 mi (1,356.31 km) |
| Middletown to Spanaway (Washington) | 1,963.03 mi (3,159.19 km) |
| Middletown to Spanish Fork (Utah) | 1,442.60 mi (2,321.64 km) |
| Middletown to Spanish Lake (Missouri) | 316.84 mi (509.91 km) |
| Middletown to Spanish Springs (Nevada) | 1,867.71 mi (3,005.78 km) |
| Middletown to Sparks (Nevada) | 1,871.27 mi (3,011.51 km) |
| Middletown to Spartanburg (South Carolina) | 342.39 mi (551.03 km) |
| Middletown to Spearfish (South Dakota) | 1,053.43 mi (1,695.33 km) |
| Middletown to Speedway (Indiana) | 102.12 mi (164.35 km) |
| Middletown to Spencer (Iowa) | 613.13 mi (986.73 km) |
| Middletown to Spokane (Washington) | 1,732.97 mi (2,788.95 km) |
| Middletown to Spokane Valley (Washington) | 1,723.77 mi (2,774.13 km) |
