| Middletown to Santa Rosa (California) | 2,045.10 mi (3,291.28 km) |
| Middletown to Santaquin (Utah) | 1,451.90 mi (2,336.61 km) |
| Middletown to Santee (California) | 1,865.21 mi (3,001.76 km) |
| Middletown to Sapulpa (Oklahoma) | 684.32 mi (1,101.30 km) |
| Middletown to Saraland (Alabama) | 633.96 mi (1,020.26 km) |
| Middletown to Sarasota (Florida) | 846.98 mi (1,363.09 km) |
| Middletown to Sarasota Springs (Florida) | 849.54 mi (1,367.20 km) |
| Middletown to Saratoga (California) | 2,030.63 mi (3,267.98 km) |
| Middletown to Saratoga Springs (New York) | 601.79 mi (968.49 km) |
| Middletown to Saratoga Springs (Utah) | 1,455.03 mi (2,341.65 km) |
| Middletown to Sartell (Minnesota) | 654.93 mi (1,054.01 km) |
| Middletown to Satellite Beach (Florida) | 811.53 mi (1,306.04 km) |
| Middletown to Sauk Rapids (Minnesota) | 651.49 mi (1,048.47 km) |
| Middletown to Sault Ste. Marie (Michigan) | 482.16 mi (775.96 km) |
| Middletown to Savage (Minnesota) | 586.08 mi (943.20 km) |
