| Middletown to Enterprise (Nevada) | 1,694.66 mi (2,727.30 km) |
| Middletown to Enumclaw (Washington) | 1,942.88 mi (3,126.76 km) |
| Middletown to Ephrata (Pennsylvania) | 436.56 mi (702.58 km) |
| Middletown to Erie (Colorado) | 1,096.05 mi (1,763.93 km) |
| Middletown to Erie (Pennsylvania) | 288.03 mi (463.53 km) |
| Middletown to Erlanger (Kentucky) | 36.01 mi (57.95 km) |
| Middletown to Escanaba (Michigan) | 453.05 mi (729.12 km) |
| Middletown to Escondido (California) | 1,862.20 mi (2,996.91 km) |
| Middletown to Española (New Mexico) | 1,206.85 mi (1,942.24 km) |
| Middletown to Essex (Maryland) | 422.98 mi (680.73 km) |
| Middletown to Essex Junction (Vermont) | 671.81 mi (1,081.18 km) |
| Middletown to Estelle (Louisiana) | 742.26 mi (1,194.55 km) |
| Middletown to Estero (Florida) | 915.53 mi (1,473.41 km) |
| Middletown to Euclid (Ohio) | 207.67 mi (334.21 km) |
| Middletown to Eufaula (Alabama) | 526.47 mi (847.27 km) |
