| Middletown to Elyria (Ohio) | 175.67 mi (282.71 km) |
| Middletown to Emeryville (California) | 2,034.07 mi (3,273.51 km) |
| Middletown to Emmaus (Pennsylvania) | 474.42 mi (763.50 km) |
| Middletown to Emporia (Kansas) | 639.56 mi (1,029.26 km) |
| Middletown to Encinitas (California) | 1,874.56 mi (3,016.82 km) |
| Middletown to Endicott (New York) | 469.51 mi (755.60 km) |
| Middletown to Endwell (New York) | 472.01 mi (759.63 km) |
| Middletown to Englewood (Colorado) | 1,096.21 mi (1,764.18 km) |
| Middletown to Englewood (Florida) | 873.56 mi (1,405.86 km) |
| Middletown to Englewood (New Jersey) | 556.43 mi (895.49 km) |
| Middletown to Englewood (Ohio) | 25.14 mi (40.46 km) |
| Middletown to Enid (Oklahoma) | 765.32 mi (1,231.67 km) |
| Middletown to Ennis (Texas) | 845.63 mi (1,360.91 km) |
| Middletown to Ensley (Florida) | 641.62 mi (1,032.58 km) |
| Middletown to Enterprise (Alabama) | 570.98 mi (918.91 km) |
