| Middlesex to Yonkers (New York) | 41.97 mi (67.55 km) |
| Middlesex to Yorba Linda (California) | 2,400.08 mi (3,862.56 km) |
| Middlesex to York (Pennsylvania) | 124.89 mi (200.99 km) |
| Middlesex to Yorktown (Indiana) | 579.81 mi (933.12 km) |
| Middlesex to Yorkville (Illinois) | 729.16 mi (1,173.47 km) |
| Middlesex to Youngstown (Ohio) | 323.21 mi (520.15 km) |
| Middlesex to Youngsville (Louisiana) | 1,219.53 mi (1,962.64 km) |
| Middlesex to Ypsilanti (Michigan) | 486.20 mi (782.46 km) |
| Middlesex to Yuba City (California) | 2,471.95 mi (3,978.22 km) |
| Middlesex to Yucaipa (California) | 2,357.86 mi (3,794.61 km) |
| Middlesex to Yucca Valley (California) | 2,322.80 mi (3,738.19 km) |
| Middlesex to Yukon (Oklahoma) | 1,308.71 mi (2,106.16 km) |
| Middlesex to Yulee (Florida) | 792.55 mi (1,275.49 km) |
| Middlesex to Yuma (Arizona) | 2,268.38 mi (3,650.61 km) |
| Middlesex to Zachary (Louisiana) | 1,156.29 mi (1,860.87 km) |
