| Middlesex to University Place (Washington) | 2,396.57 mi (3,856.90 km) |
| Middlesex to Upland (California) | 2,387.88 mi (3,842.92 km) |
| Middlesex to Upper Arlington (Ohio) | 452.96 mi (728.96 km) |
| Middlesex to Upper Grand Lagoon (Florida) | 956.38 mi (1,539.14 km) |
| Middlesex to Upper Montclair (New Jersey) | 24.35 mi (39.19 km) |
| Middlesex to Urbana (Illinois) | 721.25 mi (1,160.75 km) |
| Middlesex to Urbana (Maryland) | 173.39 mi (279.05 km) |
| Middlesex to Urbana (Ohio) | 488.13 mi (785.56 km) |
| Middlesex to Urbandale (Iowa) | 1,004.33 mi (1,616.31 km) |
| Middlesex to Utica (New York) | 178.19 mi (286.77 km) |
| Middlesex to Uvalde (Texas) | 1,624.91 mi (2,615.04 km) |
| Middlesex to Vacaville (California) | 2,505.66 mi (4,032.46 km) |
| Middlesex to Vadnais Heights (Minnesota) | 988.38 mi (1,590.64 km) |
| Middlesex to Vail (Arizona) | 2,083.96 mi (3,353.81 km) |
| Middlesex to Valdosta (Georgia) | 832.02 mi (1,339.01 km) |
